Homeopathy – these Boots are made for walking

On Saturday at 10:23, three hundred activists will take part in a homeopathic “overdose”: they will consume several times the recommended dose of a homeopathic “remedy” and see what happens.

Normally exceeding the dose on a medicine would be a very bad idea. However, most homeopathic “remedies” are pharmacologically inactive; they are either plain water, or sugar pills.

As readers will probably know, most homeopathic “remedies” are what’s called 30C. That is, the source ingredient (or “mother tincture” in homeopathic parlance) is diluted 1 part in 100, 30 times. That’s 1 part in 1060. That’s a huge number: 1 part in
1,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000

It far exceeds the Avogadro constant, which is how we know that there is no active ingredient in the final homeopathic “remedy”: there is no chance of a single molecule of the original substance appearing in the final “remedy”.

So we can be sure that taking an “overdose” of a homeopathic “remedy” will not cause any ill effects, except perhaps a sugar rush from the lactose pills.

So why are they doing it? It’s a protest against Boots continuing to stock homeopathic “remedies”, despite admitting that there is no evidence that they are effective.

So what, you might think. Boots are a company, and can sell whatever they want in order to make money. Well, it’s a bit more complicated than that. They are pharmacists; they provide medical advice and we are entitled to demand that they act in an ethical way, as per their own code of conduct.

They are basically selling medical products that they know have no therapeutic effect beyond placebo, on the basis that there is demand for them.

Compare and contrast the following products:

How is the average customer, who probably won’t be particularly knowledgeable about Homeopathy, supposed to know that only one of them has any actual arnica in it? How can it be OK for the homeopathic product to have things listed as ingredients that are not actually present in the product? I might as well sell an empty jar that I claim has fairy dust in, and list it’s ingredients as “Fairy Dust”.

That’s the point of the event: to increase awareness of what Homeopathy really is; to educate laypersons as to its (lack of) efficacy; to put pressure on pharmacists to not supply products that are known to be ineffective.

Read more: Quackometer, Thinking is Dangerous, Apathy Sketchpad, Quackometer (again), Stuff and Nonsense, and the Lay Scientist

For information on the 10:23 campaign, visit the 10:23 website

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Better late than never

OK, I know. I’ve been busy (read: lazy) and haven’t blogged for months.
Still, there’s one coming in the next day or two, promise.

Watch this space

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Neal’s Yard quacking chickens

Puzzlebobble, on the Bad Science forum tipped us off to what should have been an interesting exchange of ideas.

The Guardian Ethical Living Blog have been doing a series of Q&A articles, where the public can post questions and the featured company will answer them.

Neal’s Yard Remedies, purveyors of herbal and homeompathic remedies, as well as a ton of skincare products and some cheese, were meant to hang around for four days answering the questions put to them. I suspect they were expecting a nice bit of free publicity, and questions like “Your ginseng, coconut and willow sap facial cleanser is fab – can I use it on my fish?”. Instead they got a bit of a shock.

From the beginning, the majority of the questions were of a sceptical nature, which I found pleasantly surprising – too often these sorts of things are full of gullible people who argue along the lines of “you can’t prove it’s false, therefore it’s an equally valid viewpoint”.

After many, many questions, NYR must have realised that it had gone badly wrong for them. So they bottled it.

have just had a chat with NYR.

Unfortunately, despite previous assurances that they would be participating in this blog post, I’ve now been told they ‘will not be taking part in the debate’.

So yes, as several people have pointed out, this has become something of ‘You Ask’, rather than a ‘You Ask, They Answer’. I’m still hoping NYR will reconsider.

Unable to mount any credible defence of their evidence free products, they bailed.

I guess questions such as these were too difficult for them.

you sell a multitude of products for a wide variety of medical conditions, some of which are serious or life threatening.

Please could you explain what level of evidence of efficacy you require before stocking any product?

If, as I suspect, the level of evidence of efficacy is poor then will you tell us what, if any, studies are done to look for harmful side-effects? How are these studies conducted? Furthermore please show us the power calculations for these studies.

Surely you don’t view it as ethical to sell products which are of unproven benefit and which you don’t even know are safe?

According to the website:

Aromatherapy alleviates stress, releases tension and eliminated toxins held in the body.

I’ll buy the relief of stress and tension, especially if combined with massage, but what evidence is there for the elimination of toxins held in the body? What evidence is there that these toxins exist in the first place?

Your website states that:

The correct homoeopathic remedy will stimulate a sick person’s vitality to send healing energy where it is needed

1) what do you mean by “vitality” and how does a homeopathic remedy stimulate it?

2) what is “healing energy”? What units is it measured in and where does it come from?

And many many more. They’ve really shot themselves in the foot, and it looks especially bad, as according to the Guardian moderators, they were working on the answers, would be jumping in soon, and we should watch this space. So they started to think about it, realised they had no answer, and ran away.

Classic. On a serious note, this does show the utter paucity of the evidence for most “alternative medicine” – if they had decent evidence I’m sure they would have engaged with the questions.

For more, check out blog posts by Holfordwatch, Thinking is dangerous and Marcher Lord.

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ASA rules on POM wonderful

Back in November, I blogged about a complaint I put in to the ASA regarding an advert for POM wonderful pomegranate juice. They were implying that drinking their juice would result in health benefits due to the consumption of antioxidants.

As I said at the time, the evidence on the health benefits of antioxidants is sketchy at best, and there’s certainly insufficient evidence to claim that it can “cheat death”. I complained to the ASA (they received 23 complaints altogether), and last week they published their adjudication.

I’m happy to report that the complaint was upheld; “the ad breached CAP Code clause 7.1 (Truthfulness)”.

the claim was ambiguous and if read as a health claim, rather than an obvious untruth, it was capable of objective substantiation. We considered the evidence submitted by POM Wonderful to support the antioxidant benefits of pomegranate juice but concluded that it fell short of showing any direct relation between consuming the product and a longer life

Great. But not that great. I complained back in November, and they are ruling in April. That means that the ad could potentially have been on display for 5 months. The only sanction the ASA seems to have available is to instruct the company not to use the ad again.

I think the ASA needs more powers to retrospectively fine companies that breach the code, and they need the courage to use those powers.

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White lies?

There’s an interesting post on the Guardian science blog. The subheading sums it up nicely.  

Homeopathic remedies such as essence of crop circle and ‘F sharp minor’ may sound daft but they have a vital role to play in modern medicine

The post was written by Michael Brooks, the author of 13 things that don’t make sense. which has chapters such as “Most of the universe is missing”, and “Methane from Martians”. The book looks like an interesting popular science book. I haven’t read it myself though. Mr Brooks wades straight in with

Should homeopathy be available on the NHS? Absolutely – it’s possibly the safest, most ethical and most effective placebo there is.

So homeopathy is safe, ethical, and an effective placebo? Homeopathic remedies are certainly safe in themselves – they could hardly be otherwise, seeing as there is not a molecule of the original substance in them; they have no biochemical effect at all. However, there is plenty of evidence that homeopaths suggest their treatments are preferable to proven medicine, thereby encouraging patients to choose their placebo instead. Ethical, well is it ethical to deceive your patients; to claim that they are receiving an effective treatment when they are not? We’ll come back to this. I agree with his third statement – homeopathy is certainly an effective placebo, but it’s nothing more than that.

Where money is truly wasted is in trying to find evidence that homeopathy works.
So he’s advocating a treatment for patients, but doesn’t want to find out whether it works or not?
If you think that what passes for homeopathy today can be properly assessed by modern science, it should only take a visit to a homeopathic pharmacy to change your mind. … On the shelves I found remedies made from “F sharp minor”, “Gog and Magog, Oaks at Glastonbury”, “Flapjack” and “Crop Circle”
If something cannot be properly assessed by modern science, it has no place in evidence based medicine.
During my research I came across perfectly sane people whose initial scepticism had been blown away after their reluctant use of homeopathic treatments was followed by dramatic improvements in their symptoms. But anecdote, however impassioned, is not scientific evidence – there are always too many unknowns behind each success story.
Agreed. The plural of anecdote is not data.
Then it gets even more bizarre.

I would certainly agree with the vast majority of scientists who say that homeopathy is almost certainly no more effective than placebo. But there are two qualifications I should make about that statement – and they make all the difference. The first qualification is that the claim homeopathy doesn’t work is a prejudice, not a scientifically proven fact. The second qualification is much more important. I don’t actually know what “no more effective than placebo” means. And neither does anyone else.

All of the evidence shows that homeopathy performs no better than placebo. How is the conclusion that it therefore doesn’t work a prejudice? And the statement “no more effective than placebo” is pretty straightforward; one group of patients is given an inert sugar pill, another group is given the treatment to be tested. If the second group shows the same rate of improvement as the first, then the treatment is ”no more effective than placebo”. Everyone working in medical trials knows what that statement means.

In fact, the phrase’s negative connotations are undeserved. Let’s not forget that placebos are medically useful, and doctors know it.

Of course. No-one is denying that placebo has an important role to play in medicine; just that homeopathy doesn’t have any effect more than that; it doesn’t do what the homeopaths claim it does.

In 2003, a survey found that 48% of Danish GPs use what they regarded as a placebo intervention …  half of US physicians admit to regularly prescribing placebo – usually vitamins or analgesics …  Giving a placebo is not the same as doing nothing, which means that sometimes prescribing a placebo is better than doing nothing.

Doctors are well aware of how and when it is appropriate to prescribe a placebo. My opinion is that it should be avoided as much as possible, as we should be avoiding the old fashioned paternal approach that you don’t need to understand what the doctor is trating you with. However, when doctors prescribe placebo, they are not subscribing to the mystical mumbo jumbo, anti-science agenda of the homeopaths.

Using placebos effectively is difficult, however. Regulations governing cost and evidence-based prescribing prevent a pharmacy from dispensing something recognised as a placebo … With homeopathy, that problem is side-stepped. Homeopaths tend to believe in what they are doing, so there’s no deception

The problem is that if doctors refer to homeopaths, they are lending credibility to a system that is complete nonsense. You might as well refer patients to witch doctors, as they probably “tend to believe in what they are doing” too. Feel free to make use of the placebo effect, but the NHS shouldn’t be endorsing homeopathy as a whole in order to do so.  Stolen from the comments on the article: “allowing homeopaths to continue to work their ‘magic’ privately while also giving them legitimacy within the NHS, is a very dangerous game.” It’s also worth noting that the placebo effect is only useful in minor, self-limiting conditions. That is, it will help with conditions that will probably get better anyway, but will not have any benefit for serious conditions like AIDS &c. Bearing in mind that many homeopaths believe that their magic pills can help with more serious diseases, referring people to a homeopath could well lead to them not seeking proper medical attention for something serious. Homeopaths should be kept as far away from the NHS as possible!  

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MMR Hate Mail

Your favourite venom filled rag, and mine, has decided to poke the MMR media hoax with a stick again, to see if it’s still alive.

The story concerns a five year old girl who, just after receiving the MMR jab, was admitted to hospital with deteriorating health problems. Six months later she has difficulty speaking and walking, and is unable to feed herself.

My heart goes out to the little girl’s mother, it really does, but it does seem premature to place the blame for this on the MMR jab. The child had suffered some brain damage very young, due to a herpes virus (presumably herpes encephalitis). At the time

Doctors feared she would suffer from developmental problems as a result, but to their amazement she made a complete recovery and grew up as a normal, healthy little girl

Also

Doctors are baffled by her mystery condition and continue to carry out tests to diagnose it and search for a way forward.

They have told Melody’s mother Alicia Ellis, 25, there is no reason to believe the MMR vaccine has anything to do with her condition.

So, no-one yet knows what has caused Melody’s condition, but there is no particular reason to posit a link with MMR, other than the timing. But the Mail knows better, and with the tone of the article it implies that MMR is to blame.

Until she had the MMR jab Melody Brook was a bewitching little girl who loved to sing and dance.

Two days later the five-year-old started to limp and fall over and before long she couldn’t walk.

However, Miss Ellis is convinced [MMR] is the only logical explanation and there could be a connection to a neurological problem she had as a newborn baby.

Miss Ellis, from Leeds, said: ‘Show me the evidence that it’s not linked to the MMR jab and I might be all right, but they can’t.

To clarify; doctors predicted developmental problems from her herpes infection, and have said that there is no reason to think that MMR is to blame. Having said that, it shouldn’t be ruled out at this stage either; it is possible that the MMR jab combined with her earlier infection triggered an adverse reaction – we just don’t know yet.

Of course, if it does turn out that MMR triggered this reaction, and therefore children who have had the herpes infection would be unable to receive MMR, they would be completely dependent on herd immunity (i.e. a high level of immunisation in the community) to protect them against measles, mumps and rubella. That very herd immunity is being reduced and undermined by articles like this which sow seeds of doubt in parent’s minds and will lead to a lower MMR uptake.

The Mail also couldn’t resist bringing up the utterly discredited link between MMR and autism.

Safety fears resulted in some parents boycotting MMR over a possible link with autism and bowel disease following a controversial 1998 study by Dr Andrew Wakefield and colleagues published in the medical journal The Lancet.

The MMR vaccine has been surrounded by controversy, amid claims there could be a link to autism

For “controversial 1998 study” that should read “discredited and debunked 1998 study”.

While the UK still has trouble with MMR uptake, which will certainly lead to increased measles outbreaks, it is extremely irresponsible of the Mail to publish the piece with this tone and implications. They could have reported it in a much more balanced way, emphasizing the proven safety record of MMR. But that probably doesn’t sell quite as many papers.

Thanks to posters at Bad Science forums for inspiration. Another good post on this is over at JDC325.

PS: It’s very telling that no comments are being accepted for this story either.

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Bunch of pricks

 

Acupuncture

Acupuncture

As reported today in the Guardian and the BBC, acupuncture does provide pain relief. Amusingly, the BBC headline is “ Acupuncture ‘works for headaches’ “. Well, that’s not really an accurate representation of the study.

Yes, patients receiving acupuncture do get pain relief. But before you start getting your auras cleansed and worrying about your chakras, the report also found that patients undergoing ’sham’ acupuncture (which is where the needles are put in the wrong place or not inserted at all) experienced a similar level of pain relief.

So what does this tell us? That the mind can effect the biochemistry of the body, that pain can be blocked without pharmaceutical interventions, and that the benefits of acupuncture have nothing to do with meridians.

This is nothing new; studies showing this have been published before, and some show that the brain produces its natural painkillers when acupuncture is being undertaken. What remains unclear is whether it’s the physical insertion of needles that stimulates this natural painkilling ability, or whether it’s purely placebo. It could be either, or a combination of the two, and comparing the different types of sham acupuncture could reveal the truth here.

I find the whole are of placebo fascinating. It’s about how the whole cultural meaning of a treatment and a patient’s expectations can have a beneficial effect. 

So by all means go to an acupuncturist when you have a migraine, but let’s not pretend that chakras, meridians and chi have any basis in fact.

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CAM article in Nursing Times

Thanks to Dr*T on the Bad Science forum, I was pointed to an article on complimentary and alternative medicine (CAM) in the Nursing Times.

CAM is news, no doubt, so there’s no problem with the NT publishing an article about it per se. However I would expect it to be rigorous in its examination of the evidence base for the treatments discussed, and generally sceptical of unsupported claims. Is that the case? Let’s find out. Read the rest of this entry »

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Contemporary is not a synonym for modern

A trailer for The Long View on radio 4 this morning described it something like this (from memory):

Using history to shine a light on contemporary events

And on the Long View website, it’s described as:

the series which looks for the past behind the present, and explores a moment in history which illuminates a contemporary debate

Grr! The BBC really ought to know that contemporary is not a synonym for modern. Contemporary means “of the same time as”, so a Shakespeare play for example, described as being “in a contemporary style” should be performed in Elizabethan costume.

In this context, “a moment in history which illuminates a contemporary debate” should illuminate a debate taking place at the same time as the historic event!

They’re obviously just using contemporary so they can sound a bit trendy, as people, especially estate agents, absolutely love describing anything modern as contemporary. Whenever I see a sign for “contemporary apartments” I want to write “contemporary with what?” underneath it.

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Regulatory bodies

As reported in the Independent, and the Press Association, the Health Professions Council have recommended to Alan Johnson the Secretary of State for Health that:

The Health Professions Council (HPC) has made a formal recommendation to the Secretary of State for Health advising that Medical Herbalists, Acupuncturists and traditional Chinese Medicine Practitioners should be regulated.

This follows the ‘Department of Health Steering Group on the Statutory Regulation of Practitioners of Acupuncture, Herbal Medicine, Traditional Chinese Medicine and Other Traditional Medicine Systems Practised in the United Kingdom’ report that was published in May 2008.

The report proposed that the HPC should be the statutory regulator for acupuncturists, medical herbalists and traditional Chinese medicine practitioners which are currently not statutorily regulated. In response to the report, the Secretary of State for Health announced that a consultation would be held on the report’s recommendations.

The alternative practices concerned seem to be positive about this (some of the links just discuss the original report); The National Institute of Medical Herbalists and The British Acupuncture Council both welcomed it, but I couldn’t find anything on it from the Association of Traditional Chinese Medicine or the Foundation for Research into Traditional Chinese Medicine.

Surely any person or body that dishes out medical or health interventions or advice should be regulated? At the moment, for example, anyone can call themselves a nutritionist and start handing out dietary supplements. No medical training is required, so symptoms of medical problems become hard to spot. And that’s being kind – regulation is also necessary to weed out predatory practitioners who would profit from vulnerable people’s ill health with dangerous and possibly fatal consequences.

So should we welcome this recommendation? On the one hand, anything that will make CAM practitioners adhere to a code of ethics must be a good thing. However, the history of CAM regulation is not exactly a beacon of unimpeachable standards. The Society of Homeopaths, for example, have glaringly and persistently refused to take action against its members breaching its code of ethics. There’s no point having a regulatory body that does not enforce its own code; that simply exists to advertise and promote its own members interests. This is amply demonstrated at Letting off steam, DC, and Quackometer.

I’m not suggesting that the HPC regulation will be as bad as that, but it looks to me as if it will predominately be concerned with ensuring that people don’t use the title of “acupuncturist” without first being registered with the BAcC.

What we really need is a watchdog to take CAM practitioners to task when they make misleading or unsubstantiated claims or do anything that endangers the public. Such a body exists, and has been dubbed Ofquack. However, like a duck, it’s utterly toothless.

Until the CAM community are willing to get to grips with the rogues in their midst, until they can hold themselves to normal standards of evidence, until they can demonstrate that they take their responsibility to protect public health seriously, they will always appear to be quacks.

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